Oligosaccharide model of the vascular endothelial glycocalyx in physiological flow

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Oligosaccharide model of the vascular endothelial glycocalyx in physiological flow

Experiments have consistently revealed the pivotal role of the endothelial glycocalyx layer in vasoregulation and the layer's contribution to mechanotransduction pathways. However, the exact mechanism by which the glycocalyx mediates fluid shear stress remains elusive. This study employs atomic-scale molecular simulations with the aim of investigating the conformational and orientation properti...

متن کامل

The Endothelial Glycocalyx Promotes Homogenous Blood Flow

P. Mason McClatchey, Michal Schafer, Kendall S. Hunter, Jane E. B. Reusch 5 6 7 Division of Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, 8 Colorado USA 9 10 Department of Medicine, Denver VA Medical Center, Denver, Colorado USA 11 12 Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, 13 Colorado USA 14 15 Division of Cardiology, Depar...

متن کامل

Mechanotransduction and flow across the endothelial glycocalyx.

In this inaugural paper, we shall provide an overview of the endothelial surface layer or glycocalyx in several roles: as a transport barrier, as a porous hydrodynamic interface in the motion of red and white cells in microvessels, and as a mechanotransducer of fluid shearing stresses to the actin cortical cytoskeleton of the endothelial cell. These functions will be examined from a new perspec...

متن کامل

the effects of changing roughness on the flow structure in the bends

flow in natural river bends is a complex and turbulent phenomenon which affects the scour and sedimentations and causes an irregular bed topography on the bed. for the reason, the flow hydralics and the parameters which affect the flow to be studied and understand. in this study the effect of bed and wall roughness using the software fluent discussed in a sharp 90-degree flume bend with 40.3cm ...

Loss of the endothelial glycocalyx links albuminuria and vascular dysfunction.

Patients with albuminuria and CKD frequently have vascular dysfunction but the underlying mechanisms remain unclear. Because the endothelial surface layer, a meshwork of surface-bound and loosely adherent glycosaminoglycans and proteoglycans, modulates vascular function, its loss could contribute to both renal and systemic vascular dysfunction in proteinuric CKD. Using Munich-Wistar-Fromter (MW...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Microfluidics and Nanofluidics

سال: 2018

ISSN: 1613-4982,1613-4990

DOI: 10.1007/s10404-018-2037-5